Journal
NATURE METHODS
Volume 9, Issue 12, Pages 1185-U76Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2221
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Funding
- Ministerio de Educacion y Ciencia (Spain) [CSD2007-00050]
- US National Institutes of Health/National Human Genome Research Institute [1R01MH090941-01]
- European Union 7th Framework integrating project Revolutionary Approaches and Devices for Nucleic Acid Analysis (READNA) [Health-F4-2008-201418]
- European Union 7th Framework project European Sequencing and Genotyping Infrastructure (ESGI) [262055]
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Because of ever-increasing throughput requirements of sequencing data, most existing short-read aligners have been designed to focus on speed at the expense of accuracy. The Genome Multitool (GEM) mapper can leverage string matching by filtration to search the alignment space more efficiently, simultaneously delivering precision (performing fully tunable exhaustive searches that return all existing matches, including gapped ones) and speed (being several times faster than comparable state-of-the-art tools).
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