4.8 Article

Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

Journal

NATURE METHODS
Volume 9, Issue 9, Pages 889-895

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2114

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Funding

  1. Presidential Early Career Award for Scientists and Engineers
  2. Army Research Office Young Investigator Award
  3. National Science Foundation CAREER Award
  4. Office of Naval Research Young Investigator Award
  5. National Institutes of Health Director's New Innovator Award from the Office of the Director, National Institutes of Health [DP2OD006427]
  6. Directorate For Engineering [0930501] Funding Source: National Science Foundation
  7. Directorate For Engineering
  8. Div Of Chem, Bioeng, Env, & Transp Sys [0954482] Funding Source: National Science Foundation
  9. Div Of Chem, Bioeng, Env, & Transp Sys [0930501] Funding Source: National Science Foundation

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We discuss unique features of lens-free computational imaging tools and report some of their emerging results for wide-field on-chip microscopy, such as the achievement of a numerical aperture (NANA) of similar to 0.8-0.9 across a field of view (FOV) of more than 20 mm(2) or an NANA of similar to 0.1 across a FOV of similar to 18 cm(2), which corresponds to an image with more than 1.5 gigapixels. We also discuss the current challenges that these computational on-chip microscopes face, shedding light on their future directions and applications.

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