Journal
NATURE METHODS
Volume 9, Issue 10, Pages 969-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2173
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Funding
- Modelling Hepatocellular Carcinoma (MODHEP) Seventh Framework Program (FP7) collaborative project
- Dutch Scientific Organization (NWO) [91204082, 935170621]
- European Research Council [209700]
- InteGeR FP7 Marie Curie Initial Training Networks [PITN-GA-2007-214902]
- Israeli Science Foundation
- European Research Council (ERC) [209700] Funding Source: European Research Council (ERC)
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Regulatory DNA elements can control the expression of distant genes via physical interactions. Here we present a cost-effective methodology and computational analysis pipeline for robust characterization of the physical organization around selected promoters and other functional elements using chromosome conformation capture combined with high-throughput sequencing (4C-seq). Our approach can be multiplexed and routinely integrated with other functional genomics assays to facilitate physical characterization of gene regulation.
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