Journal
NATURE METHODS
Volume 9, Issue 7, Pages 717-U280Publisher
NATURE RESEARCH
DOI: 10.1038/NMETH.2072
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- Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
- Howard Hughes Medical Institute
- Institute of Neuroinformatics
- University of Zurich
- ETH Zurich
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Anatomy of large biological specimens is often reconstructed from serially sectioned volumes imaged by high-resolution microscopy. We developed a method to reassemble a continuous volume from such large section series that explicitly minimizes artificial deformation by applying a global elastic constraint. We demonstrate our method on a series of transmission electron microscopy sections covering the entire 558-cell Caenorhabditis elegans embryo and a segment of the Drosophila melanogaster larval ventral nerve cord.
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