Journal
NATURE METHODS
Volume 9, Issue 3, Pages 259-U54Publisher
NATURE PORTFOLIO
DOI: 10.1038/NMETH.1859
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Funding
- Deutsche Forschungsgemeinschaft (DFG)
- Swedish Research Council
- Knut och Alice Wallenbergs Stiftelse
- European Research Council
- US National Science Foundation [MCB-1021557]
- Landesgraduiertenforderung Baden-Wurttemberg
- German Federal Ministry for Education and Research [01KX0806, 01KX0807]
- Hamburg Ministry of Science and Research and Joachim Herz Stiftung
- Hamburg Initiative for Excellence in Research and the Hamburg School for Structure and Dynamics in infection
- DFG [EXC 306]
- US Department of Energy Office of Basic Energy Sciences through Photon Ultrafast Laser Science and Engineering (PULSE) Institute at the Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1120997, 1021557] Funding Source: National Science Foundation
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Protein crystallization in cells has been observed several times in nature. However, owing to their small size these crystals have not yet been used for X-ray crystallographic analysis. We prepared nano-sized in vivo-grown crystals of Trypanosoma brucei enzymes and applied the emerging method of free-electron laser-based serial femtosecond crystallography to record interpretable diffraction data. This combined approach will open new opportunities in structural systems biology.
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