Journal
NATURE METHODS
Volume 9, Issue 9, Pages 901-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2103
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Funding
- European Union [HEALTH-F4-2008-201648]
- ERC of the European Union [233226]
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The mass spectrometric identification of chemically cross-linked peptides (CXMS) specifies spatial restraints of protein complexes; these values complement data obtained from common structure-determination techniques. Generic methods for determining false discovery rates of cross-linked peptide assignments are currently lacking, thus making data sets from CXMS studies inherently incomparable. Here we describe an automated target-decoy strategy and the software tool xProphet, which solve this problem for large multicomponent protein complexes.
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