Journal
NATURE METHODS
Volume 9, Issue 7, Pages 714-U273Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1984
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Funding
- US National Institutes of Health [R01 GM095672, R01 GM089652, R01 AI072508, P01 AI083214, R01 AI085581, K99DK087928, U54 EB005149]
- Broad Institute SPARC (Scientific Planning and Allocation of Resources Committee) program
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We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease.
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