Journal
NATURE METHODS
Volume 9, Issue 6, Pages 588-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1994
Keywords
-
Categories
Funding
- US National Institutes of Health [R01GM068110, R24GM078369, R01HL093766, R01HG00249]
Ask authors/readers for more resources
The widespread use of zinc-finger nucleases (ZFNs) for genome engineering is hampered by the fact that only a subset of sequences can be efficiently recognized using published finger archives. We describe a set of validated two-finger modules that complement existing finger archives and expand the range of ZFN-accessible sequences threefold. Using this archive, we introduced lesions at 9 of 11 target sites in the zebrafish genome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
