Journal
NATURE METHODS
Volume 9, Issue 10, Pages 977-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2141
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Funding
- US National Institutes of Health
- US National Science Foundation
- Alfred P. Sloan Foundation
- Howard Hughes Medical Institute
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Morphometric studies in multicellular organisms are generally performed manually because of the complexity of multidimensional features and lack of appropriate tools for handling these organisms. Here we present an integrated system that identifies and sorts Caenorhabditis elegans mutants with altered subcellular traits in real time without human intervention. We performed self-directed screens 100 times faster than manual screens and identified both genes and phenotypic classes involved in synapse formation.
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