Journal
NATURE METHODS
Volume 9, Issue 12, Pages 1198-U96Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2213
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- Max Planck Society
- Deutsche Forschungsgemeinschaft (DFG)
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The development of methods for imaging large contiguous volumes with the electron microscope could allow the complete mapping of a whole mouse brain at the single-axon level. We developed a method based on prolonged immersion that enables staining and embedding of the entire mouse brain with uniform myelin staining and a moderate preservation of the tissue's ultrastructure. We tested the ability to follow myelinated axons using serial block-face electron microscopy.
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