Journal
NATURE METHODS
Volume 8, Issue 9, Pages 761-U107Publisher
NATURE PORTFOLIO
DOI: 10.1038/nmeth.1650
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Funding
- US National Institutes of Health [R01HG4872, R01HG4866, U01HL098957, P01DK78669]
- Crohn's and Colitis Foundation of America
- Howard Hughes Medical Institute
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Contamination is a critical issue in high-throughput metagenomic studies, yet progress toward a comprehensive solution has been limited. We present SourceTracker, a Bayesian approach to estimate the proportion of contaminants in a given community that come from possible source environments. We applied SourceTracker to microbial surveys from neonatal intensive care units (NICUs), offices and molecular biology laboratories, and provide a database of known contaminants for future testing.
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