Journal
NATURE METHODS
Volume 8, Issue 10, Pages 833-U94Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1681
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Funding
- Wellcome Trust [076113, 085475]
- US National Institutes of Health [U10 AA008401]
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We describe factored spectrally transformed linear mixed models (FaST-LMM), an algorithm for genome-wide association studies (GWAS) that scales linearly with cohort size in both run time and memory use. On Wellcome Trust data for 15,000 individuals, FaST-LMM ran an order of magnitude faster than current efficient algorithms. Our algorithm can analyze data for 120,000 individuals in just a few hours, whereas current algorithms fail on data for even 20,000 individuals (http://mscompbio.codeplex.com/).
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