Journal
NATURE METHODS
Volume 8, Issue 5, Pages 413-U58Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1585
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Funding
- US National Science Foundation [CHE-0832298, CHE-0957849, DMR-0619759]
- Research Growth Initiative of the University of Wisconsin-Milwaukee
- National Science Foundation [DMR-0537588]
- US National Institutes of Health [R01CA138882]
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Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.
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