Journal
NATURE METHODS
Volume 8, Issue 5, Pages 405-U46Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1592
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Funding
- Janelia Farm Visitor Program
- Leukemia and Lymphoma Society
- Boehringer Ingelheim Fonds
- US National Institute of General Medical Sciences [GM067761, GM084947]
- EU FP7 European Research Council
- Austrian Science Fund (FWF) [Y 510] Funding Source: researchfish
- Austrian Science Fund (FWF) [W1207] Funding Source: Austrian Science Fund (FWF)
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Existing transgenic RNAi resources in Drosophila melanogaster based on long double-stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in gene knockdown during oogenesis, an important model system for the study of many biological questions. We show that shRNAs, modeled on an endogenous microRNA, are extremely effective at silencing gene expression during oogenesis. We also describe our progress toward building a genome-wide shRNA resource.
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