Journal
NATURE METHODS
Volume 8, Issue 4, Pages S20-S29Publisher
NATURE PORTFOLIO
DOI: 10.1038/NMETH.1549
Keywords
-
Categories
Funding
- US National Science Foundation [CHE-04-00768]
- National Institutes of Health [P30 DA018310, 5R01NS031609, 5R01DE018866]
Ask authors/readers for more resources
The intracellular levels and spatial localizations of metabolites and peptides reflect the state of a cell and its relationship to its surrounding environment. Moreover, the amounts and dynamics of metabolites and peptides are indicative of normal or pathological cellular conditions. Here we highlight established and evolving strategies for characterizing the metabolome and peptidome of single cells. Focused studies of the chemical composition of individual cells and functionally defined groups of cells promise to provide a greater understanding of cell fate, function and homeostatic balance. Single-cell bioanalytical microanalysis has also become increasingly valuable for examining cellular heterogeneity, particularly in the fields of neuroscience, stem cell biology and developmental biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available