Journal
NATURE METHODS
Volume 8, Issue 8, Pages 662-U85Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1641
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We present functional ultrasound (fUS), a method for imaging transient changes in blood volume in the whole brain at better spatiotemporal resolution than with other functional brain imaging modalities. fUS uses plane-wave illumination at high frame rate and can measure blood volumes in smaller vessels than previous ultrasound methods. fUS identifies regions of brain activation and was used to image whisker-evoked cortical and thalamic responses and the propagation of epileptiform seizures in the rat brain.
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