Journal
NATURE METHODS
Volume 9, Issue 1, Pages 81-U197Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1802
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Funding
- European Research Council [EU/232814-StemCeLLMark]
- National Research Foundation of Korea [NRF-2011-357-C00093]
- The Centre van Biomedical Genetic
- The Dutch Cancer Society [KWF/Hubr2007-3956]
- EU [Tornado-KBBE-222720, EU/236954-ICSC LGR5, Ti Pharma/T3-106, KNAW/3V]
- EMBO
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he study of gene function in endodermal epithelia such as of stomach, small intestine and colon relies heavily on transgenic approaches. Establishing such animal models is laborious, expensive and time-consuming. We present here a method based on Cre recombinase-inducible retrovirus vectors that allows the conditional manipulation of gene expression in primary mouse organoid culture systems.
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