Journal
NATURE METHODS
Volume 9, Issue 1, Pages 47-55Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1800
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Funding
- Fundacion Caja Madrid
- US National Institutes of Health [1F32EY021065, EY13012]
- NATIONAL EYE INSTITUTE [R01EY013012, F32EY021065] Funding Source: NIH RePORTER
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The development of two-component expression systems in Drosophila melanogaster, one of the most powerful genetic models, has allowed the precise manipulation of gene function in specific cell populations. These expression systems, in combination with site-specific recombination approaches, have also led to the development of new methods for clonal lineage analysis. We present a hands-on user guide to the techniques and approaches that have greatly increased resolution of genetic analysis in the fly, with a special focus on their application for lineage analysis. Our intention is to provide guidance and suggestions regarding which genetic tools are most suitable for addressing different developmental questions.
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