Journal
NATURE METHODS
Volume 7, Issue 6, Pages 447-U52Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1455
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Funding
- Louise and Alan Edwards Foundation
- Canadian Institutes of Health Research
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Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.
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