Journal
NATURE METHODS
Volume 7, Issue 9, Pages 717-719Publisher
NATURE PORTFOLIO
DOI: 10.1038/NMETH.1489
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Funding
- Systems Biology Initiative (Forschungseinheiten der Systembiologie)
- US National Institutes of Health [R01GM54469, RC1GM091804]
- Deutscher Akademischer Austausch Dienst
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0840451] Funding Source: National Science Foundation
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The spatiotemporal resolution of subdiffraction fluorescence imaging has been limited by the difficulty of labeling proteins in cells with suitable fluorophores. Here we report a chemical tag that allows proteins to be labeled with an organic fluorophore with high photon flux and fast photoswitching performance in live cells. This label allowed us to image the dynamics of human histone H2B protein in living cells at similar to 20 nm resolution.
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