Journal
NATURE METHODS
Volume 7, Issue 10, Pages 821-U73Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1508
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Funding
- American Heart Association [09POST2230093]
- US National Institutes of Health [EB02185]
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We introduce quantitative dynamic footprinting microscopy to resolve neutrophil rolling on P-selectin. We observed that the footprint of a rolling neutrophil was fourfold larger than previously thought, and that P-selectin-PSGL-1 bonds were relaxed at the leading edge of the rolling cell, compressed under the cell center, and stretched at the trailing edge. Each rolling neutrophil formed three to four long tethers that extended up to 16 mu m behind the rolling cell.
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