Journal
NATURE METHODS
Volume 7, Issue 11, Pages 897-U45Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1512
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Funding
- Medical Faculty, University Bonn
- Deutsche Forschungsgemeinschaft [FL 276/3-3]
- European Community Network of Excellence [LSHB-CT-2005-512146]
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Electrical stimulation is the standard technique for exploring electrical behavior of heart muscle, but this approach has considerable technical limitations. Here we report expression of the light-activated cation channel channelrhodopsin-2 for light-induced stimulation of heart muscle in vitro and in mice. This method enabled precise localized stimulation and constant prolonged depolarization of cardiomyocytes and cardiac tissue resulting in alterations of pacemaking, Ca(2+) homeostasis, electrical coupling and arrhythmogenic spontaneous extrabeats.
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