Journal
NATURE METHODS
Volume 7, Issue 9, Pages 733-U95Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1487
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Funding
- NHLBI NIH HHS [R01 HL073305, HL73305] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000262, EB00262, R01 EB000262-09, P41 EB001046, P41 EB001046-09, R01 EB000262-08, R01 EB000262-12, P41 EB001046-08] Funding Source: Medline
- NIGMS NIH HHS [R01 GM074048-06, R01 GM074048-05, R01 GM074048-04, R01 GM074048, GM74048] Funding Source: Medline
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We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells.
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