Journal
NATURE METHODS
Volume 7, Issue 4, Pages 291-294Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1433
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Funding
- US National Science Foundation [CNS-0619926]
- Jane Coffin Childs and Burroughs-Wellcome Foundations
- Damon Runyon Cancer Research Foundation
- Howard Hughes Medical Institute
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We present fragment assembly of RNA with full-atom refinement (FARFAR), a Rosetta framework for predicting and designing noncanonical motifs that define RNA tertiary structure. in a test set of thirty-two 6-20-nucleotide motifs, FARFAR recapitulated 50% of the experimental structures at near-atomic accuracy. sequence redesign calculations recovered native bases at 65% of residues engaged in noncanonical interactions, and we experimentally validated mutations predicted to stabilize a signal recognition particle domain.
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