Journal
NATURE METHODS
Volume 7, Issue 3, Pages 206-U61Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1428
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Funding
- US National Institutes of Health [MH084691, NCRR1S10RR023454-01]
- Japanese Society for the Promotion of Science
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Using new chemically inducible dimerization probes, we generated a system to rapidly target proteins to individual intracellular organelles. Using this system, we activated Ras GTPase at distinct intracellular locations and induced tethering of membranes from two organelles, endoplasmic reticulum and mitochondria. Innovative techniques to rapidly perturb molecular activities and organelle-organelle communications at precise locations and timing will provide powerful strategies to dissect spatiotemporally complex biological processes.
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