Journal
NATURE METHODS
Volume 7, Issue 11, Pages 905-U909Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1518
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Funding
- US National Institutes of Health [MH70287, MH69122, AI48244, DK68216]
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We administered recombinant SV40-derived viral vectors (rSV40s) intravenously to mice with or without prior intraperitoneal injection of mannitol to deliver transgenes to the central nervous system (CNS). We detected transgene-expressing cells (mainly neurons) most prominently in the cortex and spinal cord; prior intraperitoneal mannitol injection increased CNS gene delivery tenfold. Intravenous injection of rSV40s, particularly with mannitol pretreatment, resulted in extensive expression of multiple transgenes throughout the CNS.
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