Journal
NATURE METHODS
Volume 7, Issue 6, Pages 443-445Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1461
Keywords
-
Categories
Funding
- EURATools-EURATrans consortium [HEALTH-F4-2010-241504]
- National Center for Research Resources [R21RR023958]
- National Institute of Child Health and Human Development [R01HD036022]
- Bundesministerium fur Bildung und Forschung [NGFN-2]
- European Young Investigator award
- Cecil H. and Ida Green Center for Reproductive Biology Sciences at University of Texas Southwestern Medical Center in Dallas
Ask authors/readers for more resources
Disrupting genes in the rat on a genome-wide scale will allow the investigation of many biological processes linked to human health. Here we used transposon-mediated mutagenesis to knock out genes in rat spermatogonial stem cells. Given the capacity of the testis to support spermatogenesis from thousands of transplanted, genetically manipulated spermatogonia, this approach paves a way for high-throughput functional genomic studies in the laboratory rat.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
