Journal
NATURE METHODS
Volume 6, Issue 11, Pages 805-U24Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1393
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Funding
- US National Institutes of Health and Fate Therapeutics
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The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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