Journal
NATURE METHODS
Volume 6, Issue 7, Pages 493-U34Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1342
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Funding
- Wellcome Trust Sanger Institute [WT077187]
- National Institutes of Health [U01-HG004080, U01-42430]
- EU
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We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation. These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background.
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