Journal
NATURE METHODS
Volume 6, Issue 8, Pages 577-580Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1346
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Funding
- Deutsche Forschungsgemeinschaft
- [587]
- [A13]
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Elucidating the function of essential proteins of complex pathogenic viruses is impeded by a paucity of complementing systems. By fusing a destabilizing domain of the FK506-binding protein to essential cytomegalovirus proteins, we generated virus mutants in which amounts of fusion proteins and viral growth can be regulated by the synthetic ligand shield-1. This conditional approach will greatly facilitate the analysis of gene functions of herpesviruses and viruses of other families.
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