Journal
NATURE METHODS
Volume 6, Issue 5, Pages 331-338Publisher
NATURE RESEARCH
DOI: 10.1038/NMETH.1321
Keywords
-
Categories
Funding
- National Institute of Mental Health [MH079197]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH079197] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Powerful methods now allow the imaging of specific mRNAs in living cells. These methods enlist fluorescent proteins to illuminate mRNAs, use labeled oligonucleotide probes and exploit aptamers that render organic dyes fluorescent. The intracellular dynamics of mRNA synthesis, transport and localization can be analyzed at higher temporal resolution with these methods than has been possible with traditional fixed-cell or biochemical approaches. These methods have also been adopted to visualize and track single mRNA molecules in real time. This review explores the promises and limitations of these methods.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available