Journal
NATURE METHODS
Volume 6, Issue 6, Pages 435-U52Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1334
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- Dresden International Graduate School for Biomedicine and Bioengineering
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We generated two complementary genomic fosmid libraries for Drosophila melanogaster and Drosophila pseudoobscura that permit seamless modification of large genomic clones by high-throughput recombineering and direct transgenesis. The fosmid transgenes recapitulated endogenous gene expression patterns. These libraries, in combination with recombineering technology, will be useful to rescue mutant phenotypes, allow imaging of gene products in living flies and enable systematic analysis and manipulation of gene activity across species.
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