Journal
NATURE METHODS
Volume 6, Issue 8, Pages 581-U44Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1352
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Funding
- National Institute of General Medical Sciences [P50 GM071508]
- National Institutes of Health Directors Pioneer Award [1DP10D003787-01]
- [08-1090-CCR-EO]
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Although modern DNA sequencing enables rapid identification of genetic variation, characterizing the phenotypic consequences of individual mutations remains a labor-intensive task. Here we describe array-based discovery of adaptive mutations (ADAM), a technology that searches an entire bacterial genome for mutations that contribute to selectable phenotypic variation between an evolved strain and its parent. We found that ADAM identified adaptive mutations in laboratory-evolved Escherichia coli strains with high sensitivity and specificity.
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