Journal
NATURE METHODS
Volume 6, Issue 4, Pages 271-273Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1308
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Funding
- UK Medical Research Council
- Lister Institute of Preventive Medicine
- EU
- Medical Research Council [G0300331, G0200489] Funding Source: researchfish
- Parkinson's UK [J-0703] Funding Source: researchfish
- MRC [G0200489, G0300331] Funding Source: UKRI
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Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
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