4.8 Article

Programmed subcellular release for studying the dynamics of cell detachment

Journal

NATURE METHODS
Volume 6, Issue 3, Pages 211-213

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1299

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Funding

  1. US National Institutes of Health
  2. National Science Foundation
  3. Howard Hughes Medical Institution
  4. Achievement Awards for College Scientists foundation
  5. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB008259] Funding Source: NIH RePORTER

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Cell detachment is central to a broad range of physiopathological changes, but there are no quantitative methods to study this process. Here we report programmed subcellular release, a method for spatially and temporally controlled cellular detachment, and present quantitative results of the detachment dynamics of 3T3 fibroblasts at the subcellular level.

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