Journal
NATURE METHODS
Volume 5, Issue 4, Pages 303-305Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1189
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Funding
- NIBIB NIH HHS [EB001991] Funding Source: Medline
- NIGMS NIH HHS [GM072015] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB001991] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM072015] Funding Source: NIH RePORTER
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Spatiotemporal regulation of protein function is a key feature of living systems; experimental tools that provide such control are of great utility. Here we report a genetically encoded system for controlling a post-translational process, protein splicing, with light. Studies in Saccharomyces cerevisiae demonstrate that fusion of a photodimerization system from Arabidopsis thaliana to an artificially split intein permits rapid activation of protein splicing to yield a new protein product.
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