Journal
NATURE METHODS
Volume 5, Issue 6, Pages 475-489Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1215
Keywords
-
Categories
Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM037006, R01GM081025, R01GM062357] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM037006-19, R01 GM081025-02, GM081025, GM037006, R01 GM037006, GM062357, R01 GM062357-07, R01 GM081025, R01 GM062357] Funding Source: Medline
Ask authors/readers for more resources
Single-molecule microscopy has evolved into the ultimate-sensitivity toolkit to study systems from small molecules to living cells, with the prospect of revolutionizing the modern biosciences. Here we survey the current state of the art in single-molecule tools including fluorescence spectroscopy, tethered particle microscopy, optical and magnetic tweezers, and atomic force microscopy. We also provide guidelines for choosing the right approach from the available single-molecule toolkit for applications as diverse as structural biology, enzymology, nanotechnology and systems biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available