Journal
NATURE METHODS
Volume 6, Issue 1, Pages 71-74Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1289
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Funding
- US National Institutes of Health Director's Pioneer award
- Fulbright award
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002644] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD000251] Funding Source: NIH RePORTER
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We developed an in vitro protein expression and interaction analysis platform based on a highly parallel and sensitive microfluidic affinity assay, and used it for 14,792 on-chip experiments, which exhaustively measured the protein-protein interactions of 43 Streptococcus pneumoniae proteins in quadruplicate. The resulting network of 157 interactions was denser than expected based on known networks. Analysis of the network revealed previously undescribed physical interactions among members of some biochemical pathways.
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