Journal
NATURE METHODS
Volume 6, Issue 1, Pages 75-77Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1282
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Funding
- European Network for Functional Integration [LSHG-CT-2005-518254]
- Sigrid Juselius Foundation,
- University of Helsinki's Research Funds
- Academy of Finland [125826, 213345, 1121413]
- Finnish Cancer Association
- Emil Aaltonen Foundation and competitive research funding of the Pirkanmaa Hospital District
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There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGF beta signaling, and revealed possible competitive interactors of p53 and c-Jun.
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