Journal
NATURE MEDICINE
Volume 24, Issue 9, Pages 1313-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41591-018-0132-5
Keywords
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Funding
- Division of Intramural Research/NIAID/NIH
- Oregon National Primate Research Center NIH [P51OD011092]
- federal funds from the National Cancer Institute, NIH [HHSN261200800001E]
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Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.
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