Journal
NATURE MEDICINE
Volume 20, Issue 2, Pages 139-142Publisher
NATURE PORTFOLIO
DOI: 10.1038/nm.3445
Keywords
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Funding
- American Foundation for AIDS Research [108302-51-RGRL]
- US National Institutes of Health [AI098487, AI106468, AI089339, AI098480, AI100699, AI074415]
- Clinical Scientist Development Award from the Doris Duke Charitable Foundation [2009034]
- European Molecular Biology Laboratory
- Tosteson postdoctoral fellowship award from Massachusetts General Hospital
- Mark and Lisa Schwartz Foundation
- Bill & Melinda Gates Foundation
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Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (T-SCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4(+) T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4(+) T-SCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.
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