Journal
NATURE MEDICINE
Volume 20, Issue 6, Pages 580-581Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3594
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Funding
- Versus Arthritis [17707, 19314] Funding Source: researchfish
- Arthritis Research UK [17707, 19314] Funding Source: Medline
- Versus Arthritis [17707, 19314] Funding Source: Medline
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Regulatory B cells exert an immunosuppressive role by secreting the cytokine interleukin-10 (IL-10). Two studies have now identified B cell derived IL-35 as both an inducer and a mediator of regulatory B cell function. IL-35 switched off inflammation in mouse models of autoimmunity, whereas its absence in B cells in mice enhanced survival after Salmonella enterica serovar Typhimurium infection. IL-35 could therefore be targeted for treating human autoimmune and infectious disease.
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