Journal
NATURE MEDICINE
Volume 20, Issue 6, Pages 587-588Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3593
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Funding
- NEI NIH HHS [R01 EY022611] Funding Source: Medline
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Although hematological cancers are genomically unstable, the mechanisms by which they evade DNA damage-induced cell death are largely unknown. A current study has revealed that the Hippo signaling pathway transcriptional regulator YAP1 activates an ABL1/p73-mediated proapoptotic effect in response to DNA damage, suggesting that YAP1 has a tumor suppressor function and that the Hippo pathway is a potential therapeutic target in human cancers.
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