Journal
NATURE MEDICINE
Volume 19, Issue 5, Pages 548-556Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3160
Keywords
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Funding
- German Research Foundation [AR232/19]
- Foundation for Research and Science Hamburg [1232/102]
- Werner Otto Foundation [4/79]
- AllerGen NCE [09B6]
- World Health Organization [A65097]
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An improved mechanistic understanding of the adaptational processes mounted during mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal interface, such as the formation of a functional synapse between invading fetal trophoblast cells, and the involvement of various maternal immune cell subsets and epigenetically modified decidual stromal cells have now been identified. These complex pathways synergistically create a tolerogenic niche in which the semiallogeneic fetus can develop. New insights into fetomaternal immune cross-talk may help us to understand the pathogenesis of pregnancy complications as well as poor postnatal health. Moreover, the effects of maternal immune adaptation to pregnancy on autoimmune disease activity are becoming increasingly evident. Thus, insights into fetomaternal immune cross-talk not only advance our understanding of pregnancy-related complications but also may be informative on how immune tolerance can be modulated in clinical settings outside the context of reproduction.
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