Journal
NATURE MEDICINE
Volume 19, Issue 10, Pages 1338-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/nm.3324
Keywords
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Funding
- US National Institutes of Health (NIH) [R01-DK55758, P01-DK088761, R01-DK099110]
- American Diabetes Association [7-11-MN-47]
- NIH [K01-DK090120-02, R03-DK099428]
- Searle Scholars Program (Chicago, Illinois)
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White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high- fat diet (HFD) feeding and cold exposure. During cold- induced ` browning' of subcutaneous fat, most ` beige' adipocytes stem from de novo- differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.
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