Journal
NATURE MEDICINE
Volume 19, Issue 11, Pages 1450-1464Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3391
Keywords
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Funding
- Charlotte Elizabeth Procter Fellowship
- European Research Council
- Deutsche Forschungsgemeinschaft
- BMBF
- Brewster Foundation
- Champalimaud Foundation
- US Department of Defense
- Komen for the Cure
- US National Institutes of Health
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As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.
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