Related references
Note: Only part of the references are listed.Developmental signaling pathways in cancer stem cells of solid tumors
Christina Karamboulas et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
James Kim et al.
CANCER CELL (2013)
A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
Jordan Berlin et al.
CLINICAL CANCER RESEARCH (2013)
Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
Antonio Jimeno et al.
CLINICAL CANCER RESEARCH (2013)
Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition
Qing Chang et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
Lisa D. Mills et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
Scott X. Atwood et al.
NATURE (2013)
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
Elissaveta Petrova et al.
NATURE CHEMICAL BIOLOGY (2013)
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
Priscilla K. Brastianos et al.
NATURE GENETICS (2013)
Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer
Emmanuel S. Antonarakis et al.
ONCOLOGIST (2013)
Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO
Victoria E. Clark et al.
SCIENCE (2013)
Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
Yu Wang et al.
ACS CHEMICAL BIOLOGY (2012)
Loss of SUFU Function in Familial Multiple Meningioma
Mervi Aavikko et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma
Anne Lynn S. Chang et al.
ARCHIVES OF DERMATOLOGY (2012)
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
Simona Blotta et al.
BLOOD (2012)
Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
Josep Domingo-Domenech et al.
CANCER CELL (2012)
The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
Yan Wang et al.
CANCER CELL (2012)
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
Jeffrey A. Magee et al.
CANCER CELL (2012)
Abstract 4818: The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor therapy
Dereck Amakye et al.
CANCER RESEARCH (2012)
Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
Bhuvaneswari Ramaswamy et al.
CANCER RESEARCH (2012)
Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
Yu Wang et al.
CHEMISTRY & BIOLOGY (2012)
A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission
Stanley B. Kaye et al.
CLINICAL CANCER RESEARCH (2012)
Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling
Nadia B. Hassounah et al.
CLINICAL CANCER RESEARCH (2012)
Cooperative Hedgehog-EGFR signaling
Doris Mangelberger et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2012)
In vitro and in vivo characterization of a novel hedgehog signaling antagonist in human glioblastoma cell lines
Pietro Ferruzzi et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Hedgehog pathway inhibition and the race against tumor evolution
Scott X. Atwood et al.
JOURNAL OF CELL BIOLOGY (2012)
Should All Women With Breast Cancer Be Tested for BRCA Mutations at the Time of Diagnosis?
Steven A. Narod
JOURNAL OF CLINICAL ONCOLOGY (2012)
High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age
Laurence Brugieres et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
Trevor J. Pugh et al.
NATURE (2012)
Dissecting the genomic complexity underlying medulloblastoma
David T. W. Jones et al.
NATURE (2012)
Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures
Sandrine Eimer et al.
NEURO-ONCOLOGY (2012)
Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
Jean Y. Tang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Aleksandar Sekulic et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis
Victoria M. Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
Mihir Rajurkar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
Gerrit J. P. Dijkgraaf et al.
CANCER RESEARCH (2011)
Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
Haiyan Tao et al.
CHEMISTRY & BIOLOGY (2011)
Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
Patricia M. LoRusso et al.
CLINICAL CANCER RESEARCH (2011)
Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
Ingrid Slade et al.
FAMILIAL CANCER (2011)
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
Elspeth M. Beauchamp et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Unusual Case of Extrapulmonary Metastatic Recurrence in a Patient With Osteosarcoma
Vivek S. Radhakrishnan et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
A crucial requirement for Hedgehog signaling in small cell lung cancer
Kwon-Sik Park et al.
NATURE MEDICINE (2011)
The cancer stem cell: premises, promises and challenges
Hans Clevers
NATURE MEDICINE (2011)
The Genetic Landscape of the Childhood Cancer Medulloblastoma
D. Williams Parsons et al.
SCIENCE (2011)
The Hedgehog's tale: developing strategies for targeting cancer
Jessica M. Y. Ng et al.
NATURE REVIEWS CANCER (2011)
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
James Kim et al.
CANCER CELL (2010)
Hedgehog pathway activation in chronic myeloid leukemia A promise for a novel combination therapeutic approach?
Zainab Jagani et al.
CELL CYCLE (2010)
Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
Stefan Peukert et al.
CHEMMEDCHEM (2010)
Targeting Hedgehog - a Cancer Stem Cell Pathway
Akil A. Merchant et al.
CLINICAL CANCER RESEARCH (2010)
Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
Henry R. Maun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Small Tumors, Intermediate Models, Big Hopes
Lillian L. Siu
JOURNAL OF CLINICAL ONCOLOGY (2010)
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway
Zainab Jagani et al.
NATURE MEDICINE (2010)
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
Jynho Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Silvia Buonamici et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway
Harald Schnidar et al.
CANCER RESEARCH (2009)
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
Frederic Varnat et al.
EMBO MOLECULAR MEDICINE (2009)
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
Olivier Nolan-Stevaux et al.
GENES & DEVELOPMENT (2009)
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao et al.
NATURE (2009)
A small molecule that binds Hedgehog and blocks its signaling in human cells
Benjamin Z. Stanton et al.
NATURE CHEMICAL BIOLOGY (2009)
Brief Report: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449.
Charles M. Rudin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
Christopher W. Wilson et al.
PLOS ONE (2009)
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
Joel M. Hyman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Hua Tian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
Yu Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Robert L. Yauch et al.
SCIENCE (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
Suzie J. Scales et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Transient inhibition of the hedgehog pathway in young mice causes permanent defects in bone structure
Hiromichi Kimura et al.
CANCER CELL (2008)
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activation
Christine Dierks et al.
CANCER CELL (2008)
Hedgehog: functions and mechanisms
Markku Varjosalo et al.
GENES & DEVELOPMENT (2008)
PTCH1 and SMO gene alterations in keratocystic odontogenic tumors
L. -S. Sun et al.
JOURNAL OF DENTAL RESEARCH (2008)
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
Georg Feldmann et al.
MOLECULAR CANCER THERAPEUTICS (2008)
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
NATURE (2008)
Basal cell carcinomas: attack of the hedgehog
Ervin H. Epstein
NATURE REVIEWS CANCER (2008)
Hedgehog signaling in development and homeostasis of the gastrointestinal tract
Gijs R. van den Brink
PHYSIOLOGICAL REVIEWS (2007)
Essential role of stromally induced hedgehog signaling in B-cell malignancies
Christine Dierks et al.
NATURE MEDICINE (2007)
Induction of sonic hedgehog mediators by transforming growth factor-β:: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
Sylviane Dennler et al.
CANCER RESEARCH (2007)
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
Matthias Lauth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
Zhenyu Ji et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Melanomas require HEDGEHOG-GLI signaling reaulated by interactions between GLI1 and the RAS-MEK/AKT pathways
Barbara Stecca et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
Georg Feldmann et al.
CANCER RESEARCH (2007)
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
Virginie Clement et al.
CURRENT BIOLOGY (2007)
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
Eli E. Bar et al.
STEM CELLS (2007)
Targeting the Hedgehog pathway in cancer
Lee L. Rubin et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
A novel somatic mouse model to survey tumorigenic potential applied to the hedgehog pathway
Junhao Mao et al.
CANCER RESEARCH (2006)
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
Suling Liu et al.
CANCER RESEARCH (2006)
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
NA Riobó et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Gli1 is important for medulloblastoma formation in Ptc1+/- mice
H Kimura et al.
ONCOGENE (2005)
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
G Rao et al.
ONCOGENE (2004)
Suppressor of fused regulates Gli activity through a dual binding mechanism
M Merchant et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen et al.
GENES & DEVELOPMENT (2002)
Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor:: A SEER update
DE McNeil et al.
MEDICAL AND PEDIATRIC ONCOLOGY (2002)
Mutations in SUFU predispose to medulloblastoma
MD Taylor et al.
NATURE GENETICS (2002)
Hedgehog signaling in animal development: paradigms and principles
PW Ingham et al.
GENES & DEVELOPMENT (2001)
A mouse model for medulloblastoma and basal cell nevus syndrome
RB Corcoran et al.
JOURNAL OF NEURO-ONCOLOGY (2001)
New guidelines to evaluate the response to treatment in solid tumors
F Duffaud et al.
BULLETIN DU CANCER (2000)
PTCH gene mutations in odontogenic keratocysts
DC Barreto et al.
JOURNAL OF DENTAL RESEARCH (2000)
New guidelines to evaluate the response to treatment in solid Tumors
P Therasse et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
M Nilsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)