Journal
NATURE MEDICINE
Volume 18, Issue 3, Pages 382-384Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2673
Keywords
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Funding
- Dana Farber/Harvard Cancer Center Lung Cancer SPORE [P50 CA090578]
- Cammarata Family Foundation
- Dana-Farber Cancer Institute
- Japan Society for the Promotion of Science (JSPS) [23659674, 21390394, 21591820]
- Grants-in-Aid for Scientific Research [21591820] Funding Source: KAKEN
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Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.
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