Journal
NATURE MEDICINE
Volume 18, Issue 2, Pages 315-321Publisher
NATURE RESEARCH
DOI: 10.1038/nm.2616
Keywords
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Funding
- GlaxoSmithKline
- Medical Research Centre
- Cambridge Experimental Medicine Centre
- National Institute for Health Research Cambridge Biomedical Research Centre
- Cancer Research UK
- New York University
- US National Institutes of Health
- Department of Health's NIHR Biomedical Research Centre
- MRC [MC_U105365007] Funding Source: UKRI
- Medical Research Council [MC_U105365007] Funding Source: researchfish
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Barrett's esophagus is an example of a pre-invasive state, for which current endoscopic surveillance methods to detect dysplasia are time consuming and inadequate. The prognosis of cancer arising in Barrett's esophagus is improved by early detection at the stage of mucosal carcinoma or high-grade dysplasia. Molecular imaging methods could revolutionize the detection of dysplasia, provided they permit a wide field of view and highlight abnormalities in real time. We show here that cell-surface glycans are altered in the progression from Barrett's esophagus to adenocarcinoma and lead to specific changes in lectin binding patterns. We chose wheat germ agglutinin as a candidate lectin with clinical potential. The binding of wheat germ agglutinin to human tissue was determined to be specific, and we validated this specific binding by successful endoscopic visualization of high-grade dysplastic lesions, which were not detectable by conventional endoscopy, with a high signal-to-background ratio of over 5.
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