4.8 Article

MDM4 is a key therapeutic target in cutaneous melanoma

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma

Inna V. Fedorenko et al.

BIOCHEMICAL PHARMACOLOGY (2011)

Article Cell Biology

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

Daniel Garcia et al.

GENES & DEVELOPMENT (2011)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Oncology

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

Federico Bernal et al.

CANCER CELL (2010)

Review Biochemistry & Molecular Biology

Mdm2-mediated ubiquitylation: p53 and beyond

J-C Marine et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo

Sarah De Clercq et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian et al.

NATURE (2010)

Article Medicine, General & Internal

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Role of Mdm4 in drug sensitivity of breast cancer cells

S. Lam et al.

ONCOGENE (2010)

Article Oncology

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

Blake Ferguson et al.

PIGMENT CELL & MELANOMA RESEARCH (2010)

Article Cell Biology

p53-based Cancer Therapy

David P. Lane et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Review Pathology

Molecular Pathogenesis of Cutaneous Melanocytic Neoplasms

Nageatte Ibrahim et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

Review Biochemistry & Molecular Biology

Blinded by the Light: The Growing Complexity of p53

Karen H. Vousden et al.

Article Oncology

Tumor-specific induction of apoptosis by a p53-reactivating compound

Elisabeth Hedstrom et al.

EXPERIMENTAL CELL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

V. K. Goel et al.

ONCOGENE (2009)

Article Developmental Biology

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

Michael Dovey et al.

ZEBRAFISH (2009)

Review Oncology

Awakening guardian angels: drugging the p53 pathway

Christopher J. Brown et al.

NATURE REVIEWS CANCER (2009)

Review Dermatology

Immunohistochemical characteristics of melanoma

Steven J. Ohsie et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2008)

Article Chemistry, Multidisciplinary

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

Federico Bernal et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Multidisciplinary Sciences

Restoration of p53 function leads to tumour regression in vivo

Andrea Ventura et al.

NATURE (2007)

Article Cell Biology

MDMX: from bench to bedside

Jean-Christophe W. Marine et al.

JOURNAL OF CELL SCIENCE (2007)

Article Biochemistry & Molecular Biology

Modeling the therapeutic efficacy of p53 restoration in tumors

Carla P. Martins et al.

Review Oncology

Regulating the p53 pathway:: in vitro hypotheses, in vivo veritas

Franck Toledo et al.

NATURE REVIEWS CANCER (2006)

Article Biochemistry & Molecular Biology

Hdmx modulates the outcome of P53 activation in human tumor cells

Mark Wade et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Cell Biology

Malignant melanoma: genetics and therapeutics in the genomic era

Lynda Chin et al.

GENES & DEVELOPMENT (2006)

Article Oncology

Amplification of CDK4 and MDM2 in malignant melanoma

V Muthusamy et al.

GENES CHROMOSOMES & CANCER (2006)

Article Oncology

Chemotherapy and targeted therapy combinations in advanced melanoma

KT Flaherty

CLINICAL CANCER RESEARCH (2006)

Review Biochemistry & Molecular Biology

Mdmx as an essential regulator of p53 activity

JC Marine et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Oncology

The role of B-RAF in melanoma

VC Gray-Schopfer et al.

CANCER AND METASTASIS REVIEWS (2005)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors

N Issaeva et al.

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

D Danovi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

D Migliorini et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)

Article Dermatology

Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma

A Demunter et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

Article Biochemistry & Molecular Biology

Dual inactivation of RB and p53 pathways in RAS-induced melanomas

N Bardeesy et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Multidisciplinary Sciences

Surfing the p53 network

B Vogelstein et al.

NATURE (2000)